A Nobel incubator

first_imgIn real estate, they say the key is location, location, location.At Harvard, the same could perhaps be said of the Nobel Prize. A single floor in a single building housed the research laboratories of three Nobel laureates. Six more were trained there, going on to receive the coveted honor after leaving Harvard. A 10th researcher followed the same path, although he was on the floor above.The place? The third floor of the Bio Labs on Divinity Avenue.Walter Gilbert, who won the 1980 Nobel Prize in chemistry, worked on the third floor as he developed ways to work out the sequence of genetic building blocks in DNA. Thirteen years earlier, in 1967, George Wald won the Nobel in medicine or physiology for his research into the biochemistry of vision; and in 1962, James D. Watson, one of the co-discoverers of the structure of DNA, was awarded the prize in medicine or physiology.George Wald worked closely with Ruth Hubbard (pictured), whom he married in 1958. In 1973, Hubbard was the first woman to be promoted to the rank of tenured professor in biology at Harvard. Courtesy of Radcliffe Archives, circa 1967Mario Capecchi, a co-winner of the Nobel in physiology or medicine in 2007 for discovering a method to create mice in which a specific gene is turned off, studied for his Ph.D. with Watson. Robert Horvitz, who studied with Watson and Gilbert, won the same category in 2002 for his research on the nematode worm Caenorhabditis elegans. Jack Strominger’s laboratory produced Richard Roberts, who won the physiology or medicine prize in 1993 for co-discovering introns in eukaryotic DNA and the mechanism of gene-splicing. The Strominger lab also hosted Roger Kornberg while he was a Harvard Junior Fellow; Kornberg became the 2006 winner in chemistry for his studies of the molecular basis of eukaryotic transcription. Martin “Marty” Chalfie, the 2008 winner in chemistry for the discovery and development of green fluorescent protein, did research on the third floor while he was an undergraduate, and Craig Mello, the 2006 co-winner in physiology or medicine for the discovery of RNA interference, did his Ph.D there. The fourth floor produced Sidney Altman, a postdoctoral researcher in the laboratory of Matthew Meselson. Altman shared the 1989 Nobel in chemistry for his work on the catalytic properties of RNA.A group photo from 1962 with Mario Capecchi (MC), Jim Watson (JW), and Wally Gilbert (WG), 1962 on one of the rhinos that graces the Bio Labs entrance. Also in the photo Fred Goldberg, Alfred Tissieres, and David Eisenberg. Courtesy of Cold Spring Harbor Laboratory ArchivesToday, Richard Losick, Maria Moors Cabot Professor and of Biology and Howard Hughes Medical Institute Professor, has his office in Room 3032. In breaks from his studies on the development of the spore-forming Bacillus subtilis, he’s researched the third-floor phenomenon.Losick remembers his neighbor Wald saying of the female praying mantis, a cannibalistic lover who eats her partner after mating, “He who loves and runs away lives to love another day,” and recounts Watson’s blunt assessment of his most famous colleague: “I have never seen Francis Crick in a modest mood.” He writes about Capecchi’s childhood starving on the streets of northern Italy while his mother sat in a Nazi jail; Horvitz’s realization that, “If you could survive a Harvard group meeting, you could survive anywhere”; and Mello’s competitive drive that led him to front a lab team in the Rhinos Club volleyball competition.Part history, part memoir, you can click here to read Losick’s story.The 2018 Nobel Prize announcements will begin Oct. 1.last_img read more

Dell EMC and VMware® – A Perfect Combination

first_imgThere are some things that just go together; fire and smoke, hugs and kisses, peanut butter and jelly (or bananas, if you’re Elvis Presley), and finally Dell EMC and VMware. You may not have thought of that last one right away, but when it comes to your data center transformation, you should. You know Dell EMC as the foundation to transform your data center with industry-leading servers, storage, data protection, networking and converged infrastructure.  You also know VMware as the most trusted virtualization platform for the data center, applications and clients. Together, we have successfully transformed data centers for the better part of two decades.But what you may not know is just how simple and easy it is to get an exceptional support experience when you are running VMware applications on Dell EMC systems.We develop and maintain an incredibly high level of VMware expertise here at Dell EMC, through training, certifications and tools (such as our technical support lab).  Dell EMC currently has 10 of only <300 VCDX professionals globally (including VMware employees), and our team holds a combined 1,900+ VMware certifications worldwide.Because of this extraordinary level of expertise, we can do things most vendors cannot when it comes to supporting VMware.  For example, during a period between February 1 to October 31, 2018, our support staff handled over 180,000 VMware-related support issues.  Of those, 97% were handled in-house. In other words, our customers only had to call Dell EMC because our team was able to determine the issue and resolve it.Now with ProSupport Plus for Enterprise, we support eligible VMware software installed on your Dell EMC systems whether you purchased the software from us or not.  Not only will we diagnose the issue, we will own the issue through resolution.At Dell EMC, we continue to listen and work hard to make your support experience even more proactive, predictive, personalized and most of all… simple.To learn more about ProSupport Plus for Enterprise, visit DellEMC.com/ProSupport-Plus.last_img read more

Logistical Experience in Health Will Be the Largest Lesson in the Exchange

first_imgFor physicians who would like information on a military career, Cima would invite his colleagues to learn more about the Air Force’s activities in healthcare. “There is a section that serves service members and their dependents, but there are also sections for search and rescue, humanitarian missions, disaster response and air medical transportation. I am certain that very good people will arise who are trained to help,” he said. In Belize, the first stop for 2015 Continuing Promise, an eight-year-old boy had been in a car accident and had two severe fractures in his arms and legs. He had surgery at the time, but because more advanced equipment was not available – a fluoroscope is the most-often used instrument to observe organs within the body – one of the two breaks did not heal properly. The original, local orthopedist submitted the case and attended the new surgery on board the ship together with the family. Experience By the middle of the mission, they had provided more than 40,000 treatments. Patients also receive medication. The number of surgeries has already exceeded 500; 60 in orthopedics alone. By Dialogo July 30, 2015 “The main thing we learned, one of the strong points, is understanding how logistics are handled for a large-scale, international health mission. I know of no other humanitarian mission as large as this one,” said Cima about the amount of materials and the bureaucratic procedures involved in preparing credentials for professionals from different countries and organizations. He said he believes that the lessons learned during the exchange can help improve the Air Force’s systems for humanitarian and disaster response missions. The largest hospital ship in the world features a level of healthcare infrastructure that many cities do not even have. There are nearly 800 beds, 12 operating rooms and 80 beds in the intensive care unit. “They needed to use their full capacity just once, when it traveled in response to the earthquake in Haiti [in 2010],” he said. The Comfort, a modified oil tanker, has a “twin”: the Mercy, which is based out of San Diego, on the US west coast, and which performs similar missions to countries in the Pacific. After concluding the treatments in Colombia on July 18, Medical Lieutenant César Cima traveled at sea for eight days before arriving in the city of Dominica, in El Seibo, Dominican Republic. The city is the next stop in the itinerary for the world’s largest hospital ship, the USNS Comfort, which is hosting the United States Southern Command’s 2015 Continuing Promise mission. In addition to healthcare personnel, the ship needs to accommodate the entire crew. “It is practically a city,” he said. “On board, there is a gym, a chapel, a supermarket and a restaurant to support the team.” The 182-day mission, which will visit11 countries, carries 1,100 people on board, including 80 physicians and approximately 200 nurses, in addition to veterinarians and engineers. In addition to a cardiologist from Brazil’s Army and a pediatrician from the country’s Navy, Cima, an orthopedist from the Air Force, is part of the first group sent by Brazil’s Ministry of Defense to participate in the exchange. In July, after completing three months of the mission, the physician returned to Brazil for a five day break – R&R, in military parlance – and spoke with the Air Force News Agency. The Brazilian orthopedist works together with one from the United States. “I participate effectively as a member of the mission, discussing cases and learning how plans for global projects are made,” he said. The two orthopedists’ routine, which may be reinforced by residents for a month, included performing triage for the first two days after arriving at a new country. When asked about the cases that made the biggest impressions on him, as a doctor, Cima told the story of a situation that, according to him, truly reflects the reason for the mission, which spends 10-15 days at cities near small ports along the coast of countries in Latin America and the Caribbean. Read the story of Medical Lieutenant César Cima, who works at Brazil’s Fortaleza Air Base (BAFZ) and narrates another aspect of the professional life of military doctors. He is participating in an exchange program as part of the 2015 Continuing Promise mission, on board the largest hospital ship in the world. “This is training and diplomacy. In almost all countries, the country’s president has visited,” Cima said. His account “It is an aid mission, because the ship has the equipment. It is not that the healthcare professionals are better or worse than the local ones, but simply, sometimes, they have more technology on board, and they provide it. Everyone was very happy because it was one of the most complex cases,” he said. last_img read more

A grand inner-city estate on half-an-acre

first_imgKaren Murphy and her dog Bella will both miss long afternoons on the veranda at their Red Hill house, but it’s time for a new family to call it home. Photo: Jono Searle.Imagine this — a summer afternoon on the veranda with both a Singapore Sling and a cool breeze vying for your attention. At the far end of your half-acre block¬, beyond its botanic-garden setting, the kids relax in the lofted pool house after hours of splashing about.And all within a short jog of Brisbane’s city centre. 39A Glenrosa Rd, Red Hill is really something special. The kitchen at 39A Glenrosa Road has hosted professional chefs catering major eventsMs Murphy also used inspiration from a Singaporean landmark to improve the existing verandas with plantation shutters and outdoor fans.More from newsMould, age, not enough to stop 17 bidders fighting for this home4 hours agoBuyers ‘crazy’ not to take govt freebies, says 28-yr-old investor4 hours ago“The first time I ever saw fans outside was up in Singapore and I thought it was such a good idea. It’s got that Raffles feel about it — we just need to be knee deep in peanut shells.” The verandas are inspired by one of the world’s most iconic hotels.Ms Murphy said the home’s broad spaces have been a backdrop for many family celebrations.“Lots of big family get-togethers have been held here over the years — 40th birthdays with marquees out the back — and in fact the deck has hosted a few string quartets.”She’d also replaced the old terracotta tiles in the garden with grey travertine and repainted the home with charcoal tones.“The pool has been completely resurfaced with something called Jewels for Pools in there so when the sun hits it in the morning, it’s got a gold rim around it, so it’s quite pretty.”The manicured landscaping and level lawn provide a connection between the main home and the Hamptons-inspired pool house.“It started out with me just wanting a place to hang out by the pool.”It certainly grew into something more than that according to Ms Murphy — so much so that it’s now available for short-stay holiday guests.“It got out of control … in a very nice way, so I ended up with the ‘pool mansion.’”“The last guests I had are a couple who were having their 10th wedding anniversary and they were looking for something special … bunkered down for the weekend, turned on the fireplace and had a great time.” 39A Glenrosa Road, Red Hill is a stunning home on half-an-acre and just a few kilometres from the CBDThe home’s owner, Karen Murphy, said although built in 2001, the house was inspired by the early 1900s colonials.“It had that very simple, beautiful architecture about it — very, very high ceilings and the breeze flows through the house,” she said.It’s a two-level, five-bedroom, four-bathroom home on a 2055sq m site, and while there was already plenty to adore, Ms Murphy used the inspiration of international travel to create something exceptional.“When I finally settled in Brisbane I just wanted to create a haven that reflected some of the nice things about the places I’ve lived in around the world.“The whole house has pretty much been rewired and rebuilt — I think I’ve replaced every door in that house.” The pool house is so impressive, it’s hosted short stay Air BnB guests.After all these years and a lot of effort, Ms Murphy said it’s time to move on and let new owners enjoy everything the home has to offer.“It needs someone to live here and love it.“It needs a family and it needs people who are going to entertain and who are going to utilise the whole property because that’s what it’s all for.“So I’m imagining a larger family with kids probably, and hopefully animals. I bought this house because I wanted a dog friendly house.”She will love seeing a new family add to the history, but admits those long afternoons on the veranda will be missed.“The back is where I’ve sat very day, every evening … it’s very calming.”last_img read more

​Poor work conditions prompt Norway’s SWF to divest textile firms

first_img“The executive board agrees with the Council on Ethics that observation no longer seems to be the appropriate action as the company is not responding to enquires from the council,” Norges Bank said, but added that it considered active ownership to be an alternative.“The fund has regular dialogue with companies on anti-corruption issues, and can benefit from that experience in a dialogue with PetroChina Co Ltd,” the bank said.A spokesman for NBIM told IPE that apart from exercising voting rights, the manager’s definition of active ownership also involves expectation documents and many forms of dialogue.Explaining its recommendation to divest from PetroChina, the council said many senior executives at the firm and its subsidiaries had been accused of accepting bribes for the award of contracts to suppliers, and that the company had not shown that its efforts to prevent corruption were effective enough.Regarding Formosa Taffeta, the council said investigations into working conditions at its factory in Vietnam had identified numerous labour rights violations.Meanwhile, at Page Industries – which is licensed to produce clothing under the Jockey and Speedo brands – a probe into conditions at one factory identified many labour-rights violations, the council said.It added that Page Industries had not provided any information to help clarify the case.At the end of 2019, the GPFG had NOK1.4bn invested in PetroChina shares, representing a 0.17% holding in the company. It had NOK1.3bn invested in Formosa Chemicals & Fibre and NOK107.5m in the subsidiary Formosa Taffeta, according to Norges Bank data.The fund had NOK134.9m invested in Page Industries at the end of last year – 0.42% of the Indian firm’s voting capital.IPE was unable to get any reaction to the Norges Bank news from Formosa Chemicals & Fibre, Page Industries or PetroChina by deadline.Exclusion return impactsExclusions led Norges Bank Investment Management (NBIM) to miss out on 1.3 percentage points of return on an accumulated basis compared with an unrestricted equity benchmark in the period from its first exclusion in 2006 to the end of 2019, the manager revealed in a report this week.It said this translated into an average annual performance of 0.04 percentage point for the equity portfolio during this period, noting that annual management costs for the SWF came to just under 0.05 of a percentage point last year.The information was disclosed in a report charting how it became the single largest shareholder in the world and the evolution of restrictions on its investments – “This is the story of how we evolved from a reluctant to an active owner,” it said.According to a graph in the report, the -1.3 percentage point return impact was for all types of exclusion. However, conduct-based exclusions had a positive effect, and coal-linked exclusions little impact. The manager of Norway’s NOK10.1trn (€970bn) sovereign wealth fund (SWF) has banished three companies from its portfolio on human rights grounds, but in the same announcement said it was holding on to major Asian oil and gas company PetroChina despite its own advisory council recommending divestment.Norges Bank, the Norwegian central bank and manager of the Government Pension Fund Global (GPFG), said it has decided to exclude Taiwan-headquartered Formosa Chemicals & Fibre and its unit Formosa Taffeta Co, alongside Indian textiles firm Page Industries, because of alleged human rights violations related to textile production in Vietnam and India, respectively.The bank said these exclusion decisions were made based on recommendations from the Council on Ethics – the GPFG’s advisory body.The bank also announced that despite the council’s recommendations since 2016 to exclude PetroChina from the SWF’s portfolio, it had instead decided to follow the company’s work on anti-corruption as part of the fund’s active ownership efforts, for a period of three years. Looking for IPE’s latest magazine? Read the digital edition here.last_img read more

Ex-Man City Nasri blames LA clinic for doping ban

first_img Promoted ContentThe Funniest Prankster Grandma And Her Grandson5 Of The World’s Most Unique Theme ParksWho’s The Best Car Manufacturer Of All Time?7 Of The Wealthiest Universities In The WorldThese Are The Best Stargazing Locations You Can Find On Earth10 Risky Jobs Some Women DoWho Earns More Than Ronaldo?11 Most Immersive Game To Play On Your Table Top6 Things Women Found Really Attractive In The 60’s7 Ways To Understand Your Girlfriend Better10 Phones That Can Easily Fit In The Smallest PocketThese Popular Hollywood Stars Got Their Start On Soap Operas Former Manchester City and Arsenal midfielder, Samir Nasri, has explained why he was caught doping. “What happened in Los Angeles ruined my season. It was a vitamin injection, legal and I had a prescription,” Nasri said. read also:Nasri denies going AWOL during coronavirus lockdown “The clinic injected me with much more product than expected.” FacebookTwitterWhatsAppEmail分享 Loading… The Frenchman moved to Antalyaspor in 2017 but was suspended for 18 months after he was found guilty of using a “prohibited method” in violation of the WADA and UEFA rules. And Nasri has blamed a legal vitamin injection clinic in Los Angeles for the incident.Advertisementlast_img read more

Djokovic still in ‘pain’ after U.S Open tennis disqualification

first_img Loading… Carreno Busta said he didn’t see the incident, but noticed the lineswoman on the ground after she was hit. He also said he didn’t think Djokovic intended to hit the official. “I was in shock,” Carreno Busta said. “I never expected this moment against Novak.” Several tennis stars were asked about Djokovic’s behavior during their news conferences Sunday in Queens. Naomi Osaka said she thinks incidents like Djokovic’s will make players “more aware” of their surroundings during matches. Serena Williams and several other players did not respond to questions about the disqualification. “I’m not going to touch that,” Williams said when asked about the decision to disqualify Djokovic. “I’m going to leave that to [reporters].” Second-seed Dominic Thiem is now the highest remaining seed in the men’s singles circuit. World No. 2 Rafael Nadal and No. 4 Roger Federer did not compete in the U.S. Open due to concerns about the coronavirus pandemic. read also:US Open: Djokovic disqualified after hitting official with ball “What happened, happened,” Thiem said Monday. “None of the other players had any influence over it. We just need to focus on ourselves. Now there is probably a better chance for all of us to win our first Grand Slam, but things didn’t change all that much.” Carreno Busta will battles Denis Shapovalov in a quarterfinal match at 8:15 p.m. EDT Tuesday. The winner will face Borna Coric or Alexander Zverev in the semifinals. FacebookTwitterWhatsAppEmail分享 Novak Djokovic felt “sad” after he was disqualified from the U.S. Open for hitting a line judge with a ball. His former coach says he is still “in pain,” while other players have said little about the incident. The top-seeded Serbian became frustrated after he failed to win the first set of a match against Pablo Carreno Busta. He turned and smacked the tennis ball toward the back wall, hitting a lineswoman in the throat. Djokovic was defaulted from the match and immediately left without speaking to the press. He later posted an apology on social media. “This whole situation has left me really sad and empty,” Djokovic wrote. “I checked on the linesperson and the tournament told me that thank God she is feeling OK. I’m extremely sorry to have caused her such stress. So unintended. So wrong. I’m not disclosing her name to respect her privacy.” Radek Stepanek, Djokovic’s friend and former coach, told CNN Tuesday that Djokovic still was distraught about his exit. “I know he is very sad inside himself and he is in pain,” Stepanek said. “He is in pain because it was unintentional and, in that moment, the pain is bigger. “And it’s hard for him because we know how hungry he is to become the player with the most Grand Slams.” The lineswoman has received an abundance of negative messages on social media since the incident. Djokovic on Monday posted a message asking his fans to support the official. “Please also remember the linesperson that was hit by the ball [Sunday] needs our community’s support too,” Djokovic wrote on Instagram. “She’s done nothing wrong at all. I ask you to stay especially supportive and caring to her during this time. From these moments, we grow stronger and we rise above.”center_img Promoted Content10 Risky Jobs Some Women DoWhat Is A Black Hole In Simple Terms?6 Incredibly Strange Facts About Hurricanes14 Hilarious Comics Made By Women You Need To Follow Right NowBest & Worst Celebrity Endorsed Games Ever Made6 Interesting Ways To Make Money With A Drone10 Phones That Can Work For Weeks Without Recharging6 Ridiculous Health Myths That Are Actually True13 kids at weddings who just don’t give a hoot5 Of The World’s Most Unique Theme ParksCan Playing Too Many Video Games Hurt Your Body?7 Things That Actually Ruin Your Phonelast_img read more

John “Kelly” Leffingwell – Brookville

first_imgJohn “Kelly” Leffingwell died April 22, 2020 at home surrounded by his family after a courageous battle with kidney cancer. Kelly was born July 22, 1960 to Bill Dick and Butzie Leffingwell in Connersville, Indiana. He is survived by wife, Missy, son, Evan, daughter-in-law, Katie, and daughter, Logan.Born an entrepreneur, Kelly had been coined “The Candy Man” at his elementary school as he would sell candy to his school friends. This skillset followed him later in life when he bought Pizza Pete at the age of 20. His hard work and determination made this a successfully ran business for more than 35 years. A legacy he’d be proud that his son and wife continue to this day. Kelly was equally proud of his daughter Logan who earned her Bachelor’s Degree in Nursing and took the driver’s seat throughout his cancer journey.Though Kelly will be sorely missed by his family and friends, they will celebrate his beautiful life and all of his achievements. One of those achievements included obtaining his Eagle Scout rank at 15 years old. His project was to clean Whitewater Canal. Additionally Kelly was an avid canoer, who enjoyed wood working, golfing, hunting, trapping, and fishing. Any opportunity to be outside, Kelly took advantage of. If he could be outside doing the above with family and friends, all the better.Kelly’s true passion in life was loving and caring for his family and friends. His selflessness shined through in his everyday life. A true good samaritan, Kelly touched so many by volunteering himself in any capacity.In his final days Kelly would talk candidly to his family and friends about going to paradise and leaving the rest of us behind. They know he is in heaven and find comfort that his light will be shining upon them until they meet again.A Celebration of Life will be held at a future date.  Everyone is encouraged to sign the online guestbook or share personal memories at www.cookrosenberger.com.  Memorial donations can be directed to the St. Michael building fund at 145 St. Michael Blvd. Brookville, IN 47012.  The staff of Cook Rosenberger Funeral Home is honored to serve the family of Kelly Leffingwell.last_img read more

Liverpool keeper Karius suffered concussion

first_imgLondon, June 5: Liverpool goalkeeper Loris Karius suffered a concussion during the UEFA Champions League final against Real Madrid, doctors who treated the German five days after the match at the Massachusetts General Hospital in Boston said.“After carefully reviewing game footage and integrating a detailed history — including his reported present and immediate post-contact subjective symptoms — physical examinations and objective metrics, we have concluded that Karius sustained a concussion during the match,” Dr. Ross Zafonte and Lenore Herget said in a statement on Monday.The German goalkeeper was at fault in two of Real Madrid’s three goals during Liverpool’s 1-3 loss in Kiev.“Karius’s principal residual symptoms and objective signs suggested that visual spatial dysfunction existed and likely occurred immediately following the event. Additional symptomatic and objectively noted areas of dysfunction also persisted. It could be possible that such deficits would affect performance,” the statement added, but did not specify when Karius suffered the concussion. IANSlast_img read more